About Regulora

What is gut-directed hypnotherapy?
What is the evidence for gut-directed hypnotherapy?
Is everyone hypnotizable?

About Regulora®

Do I need to stop my current IBS treatment to try Regulora?
What if I miss a treatment session?
Does my doctor have access to my data from the app?
Is the program difficult?
Can I continue to use Regulora after 12 weeks?

How to get Regulora®

How do I get a referral for Regulora?
How much does Regulora  cost?
Why does Regulora require a referral?
What if I have technical issues with the app?

Living with IBS

Gut-Directed Hypnosis and IBS Management

Hear Dr. Olafur Palsson—originator of the treatment protocol upon which Regulora  is based—talk about the data that support the use of gut-directed hypnotherapy in the management of IBS. You’ll also hear from Tim Rudolphi, CEO of metaMe Health, on how Regulora is changing the game for patients with IBS.

Find support and gain new insights from the community.

Woman with dark hair wearing glasses and smiling while looking at her laptop

What happens when your brain and gut are not aligned?

IBS and the Gut-Brain axis

Man with blonde curly hair listening to headphones

Looking for more from your IBS treatment?

Find out how Regulora can help

Mature female doctor wearing stethoscope while writing a prescription at her desk

Get Regulora

All you need is a referral from your doctor


Regulora® is a digital therapeutic intended to provide behavioral therapy through gut-directed hypnotherapy for adults who have been diagnosed with irritable bowel syndrome (IBS). Regulora is indicated as a 3-month treatment for patients with abdominal pain due to IBS and is intended to be used together with other IBS treatments. Regulora is intended for patients who speak and read English. Regulora may not be appropriate for patients with mental or physical impairment that would prevent interacting with a mobile video application. Regulora may not be appropriate for patients with evidence of intestinal illness that better explains IBS symptoms such as celiac disease or inflammatory bowel disease. Regulora should not be used in lieu of your current IBS medication or therapy. In a clinical trial of Regulora, side effects were low. About 1% of patients experienced abdominal pain, constipation, fatigue, or headache which was thought to be related to using Regulora.


Regulora® Instructions for Use for Patients and Physicians. metaMe Health, Inc.; April 2022.
Lacy BE, Pimentel M, Brenner DM, et al. ACG Clinical Guideline: Management of Irritable Bowel Syndrome. Am J Gastroenterol. 2021;116(1):17-44.
International Foundation for Gastrointestinal Disorders. What is IBS? Accessed August 15, 2022. https://aboutibs.org/what-is-ibs/facts-about-ibs/
The Rome Foundation. Brain-Gut Psychotherapy Referral Guide. Accessed August 15, 2022. https://theromefoundation.org/wp-content/uploads/Rome-Foundation_GastroPsych-referral-project.pdf
Miller V, Carruthers HR, Morris J, Hasan SS, Archbold S, Whorwell PJ. Hypnotherapy for irritable bowel syndrome: an audit of one thousand adult patients. Aliment Pharmacol Ther. 2015;41(9):844-855.Digital Therapeutics Alliance.
Digital Therapeutics Definition and Core Principles Fact Sheet. Accessed August 15, 2022. https://dtxalliance.org/wp-content/uploads/2021/01/DTA_DTx-Definition-and-Core-Principles.pdf